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Invitrogen
CaV2.3 Polyclonal Antibody
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FIGURE: 1 / 3
CaV2.3 Antibody (PA5-99754) in ICC/IF
Immunofluorescent analysis of CaV2.3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CaV2.3 polyclonal antibody (Product # PA5-99754) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-99754
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CACNA1E(Accession Q15878), corresponding to amino acid residues S921-P971.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CACNA1E.
Target Information
The expression of multiple classes of voltage dependent calcium channels (VDCCs) allows neurons to tailor calcium signaling to functionally discrete cellular regions. Although N-Type VDCCs exist before birth which is consistent with a role in migration, most N-Type VDCCs subunit expression is postnatal and is important in the genesis of synaptic transmission in discrete hippocampal fields.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BII; Brain calcium channel II; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide; calcium channel, voltage-dependent, L type, alpha 1E subunit; RBE-II; RBE2; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha 1E subunit; voltage-dependent calcium channel alpha1-E subunit; Voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel alpha subunit Cav2.3; Voltage-gated calcium channel subunit alpha Cav2.3
Gene Aliases: A430040I15; alpha1E; BII; CACH6; CACHA1E; CACNA1E; CACNL1A6; Cav2.3; Cchra1; DEE69; EIEE69; gm139
UniProt ID: (Human) Q15878
Entrez Gene ID: (Human) 777, (Rat) 54234, (Mouse) 12290
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
calcium ion binding
high voltage-gated calcium channel activity
voltage-gated cation channel activity
metal ion binding
low voltage-gated calcium channel activity
protein N-terminus binding
voltage-gated ion channel activity
voltage-gated ion channel
ion transport
calcium ion transport
chemical synaptic transmission
ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
behavioral fear response
regulation of heart rate
locomotory behavior
visual learning
transmission of nerve impulse
sensory perception of pain
sperm motility
regulation of ion transmembrane transport
glucose homeostasis
fear response
response to pain
behavioral response to pain
neurological system process
regulation of insulin secretion involved in cellular response to glucose stimulus
calcium ion import
membrane depolarization during action potential
regulation of somatostatin secretion
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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