Invitrogen
The use of 4% paraformaldehyde fixation, rather than formalin fixation, is recommended. A sensitive detection system is also recommended, such as a catalyzed signal amplification system. A suggested positive control for immunohistochemical applications is kidney, cultured osteoclasts.
Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems.
The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C1A/C1B; Calcitonin receptor; COPT1; CT receptor; CT-R
Gene Aliases: CALCR; Clr; CRT; CT-R; CTR; CTR1
UniProt ID: (Human) P30988, (Rat) P32214, (Mouse) Q60755
Entrez Gene ID: (Human) 799, (Rat) 116506, (Mouse) 12311
Molecular Function:
G-protein coupled receptor
antibacterial response protein
defense/immunity protein
receptor
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support