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Calcium Sensing Receptor Polyclonal Antibody

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Calcium Sensing Receptor Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Hela cells, using CASR antibody 19125-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Calcium Sensing Receptor Antibody in Western Blot (WB) — COLO 320 cells were subjected to SDS PAGE followed by western blot with 19125-1-AP (Calcium Sensing Receptor antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

19125-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 3 publications 3 publications
Immunohistochemistry (IHC)	Assay-dependent	View 2 publications 2 publications
Immunocytochemistry (ICC/IF)	1:10-1:100	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.4 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

The 60-65 kDa band detected by this antibody might represent a degradation product of CASR.

Target Information

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 EDT 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 EDT 2020

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 EDT 2019

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 EDT 2019

miR-429 and miR-424-5p inhibit cell proliferation and Ca²⁺ influx by downregulating CaSR in pulmonary artery smooth muscle cells.

American journal of physiology. Cell physiology

Li C,Qin F,Xue M,Lei Y,Hu F,Xu H,Sun G,Wang T,Guo M

Tue Jan 01 00:00:00 EST 2019

Role of autophagy in cadmium-induced testicular injury.

Human & experimental toxicology

Wang YJ,Yan J,Yin F,Li L,Qin YG,Meng CY,Lu RF,Guo L

Sun Oct 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Ca sensing receptor; calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1

Gene Aliases: CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1

UniProt ID: (Human) P41180, (Rat) P48442, (Mouse) Q9QY96

Entrez Gene ID: (Human) 846, (Rat) 24247, (Mouse) 12374

Molecular Function: G-protein coupled receptor