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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 243 and 418 of Calnexin (Uniprot ID#P27824)|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-34665 targets Calnexin in ICC, IF, IHC (P), and WB applications and shows reactivity with Human and Mouse samples.
The PA5-34665 immunogen is recombinant fragment corresponding to a region within amino acids 243 and 418 of Calnexin (Uniprot ID#P27824).
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
calnexin; CNX; major histocompatibility complex class I antigen-binding protein p88
1110069N15Rik; AI988026; CANX; CNX; D11Ertd153e; IP90; P90