Immunogen sequence: ANLEEFDISE DDIDDGFRRL FAQLAGEDAE ISAFELQTIL RRVLAKRQDI KSDGFSIETC KIMVDMLDSD GSGKLGLKEF YILWTKIQKY QKIYREIDVD
Mu-Calpain, also known as Calpain-I, and m-calpain, also known as Calpain-II, are intracellular, calcium-dependent cysteine proteases. Mu-calpain has a micromolar sensitivity (thus the mu-) as compared to the millimolar calcium sensitivity of m-calpain. The calpains have papain-like activity, thus the -pain nomenclature. Both m-calpain and mu-calpain are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain-94, ncl-2, ncl-3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain-4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV.
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Protein Aliases: 80 kDa M-calpain subunit; Calcium-activated neutral proteinase 2; CALP80; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; Calpain-2 catalytic subunit; Calpain-2 large subunit; CANP 2; CANPL2; CANPml; cysteine proteinase; M-calpain; m-calpain 80 kDa large subunit; m-calpain large subunit; mCANP; Millimolar-calpain
Gene Aliases: AI326419; CANP2; CANPL2; CANPml; Capa-2; Capa2; CAPN2; m-calpain; m-calpin; mCANP