This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-34786 targets Calreticulin in IHC (P) and WB applications and shows reactivity with Human and Mouse samples.
The PA5-34786 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 214 of Calreticulin (Uniprot ID#P27797).
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Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
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Protein Aliases: autoantigen Ro calreticulin; CABP3; CALBP; Calcium-binding protein 3; Calregulin; Calreticulin; cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; grp60; HACBP; RO; Sicca syndrome antigen A; Sicca syndrome antigen A (autoantigen Ro; calreticulin); SSA
Gene Aliases: CALR; Calregulin; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA
Molecular Function: calcium-binding protein