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Product Details
PA5-21706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 124 and 388 (O14958) of Calsequestrin 2
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11152287
Product Specific Information
Recommended positive controls: HCT116.
Predicted reactivity: Mouse (95%), Rat (96%), Dog (96%), Rabbit (96%), Chicken (90%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; Calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardiac calsequestrin
Gene Aliases: AA033488; AW146219; CASQ2; cCSQ; Csq2; ESTM52; PDIB2
UniProt ID: (Human) O14958, (Mouse) O09161
Entrez Gene ID: (Human) 845, (Mouse) 12373
regulation of heart rate
detection of calcium ion
striated muscle contraction
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
ion transmembrane transport
negative regulation of potassium ion transport
sarcomere organization
sequestering of calcium ion
protein polymerization
cardiac muscle contraction
regulation of membrane repolarization
negative regulation of ryanodine-sensitive calcium-release channel activity
cellular response to caffeine
Purkinje myocyte to ventricular cardiac muscle cell signaling
negative regulation of potassium ion transmembrane transporter activity
regulation of cardiac conduction
regulation of muscle contraction
regulation of cardiac muscle cell contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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