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Proteintech
Cardiac Troponin T Polyclonal Antibody
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FIGURE: 1 / 10
Cardiac Troponin T Antibody (15513-1-AP) in ICC/IF
Frozen tissue section of embryonic mouse heart (E12.5) was stained for cardiac troponin-T/cTnT (magenta, Cat. No Product # 15513-1-AP), CD31/PECAM-1 (white), and Arl13B (yellow, Cat. No 66739-1-Ig) with DAPI as a counterstain for visualizing the nucleus (cyan). cTnT stains cardiomyocytes and was visualized with an Alexa Fluor 555 secondary antibody and psedocolored to magenta.CD31 stains endocardial/endothe... View More
Product Details
15513-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cardiac Troponin T Fusion Protein Ag7716 (1-285 aa encoded by BC002653)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSDIEEVVE EYEEEEQEEA AVEEQEEAAE EDAEAEAETE ETRAEEDEEE EEAKEAEDGP MEESKPKPRS FMPNLVPPKI PDGERVDFDD IHRKRMEKDL NELQALIEAH FENRKKEEEE LVSLKDRIER RRAERAEQQR IRNEREKERQ NRLAEERARR EEEENRRKAE DEARKKKALS NMMHFGGYIQ KTERKSGKRQ TEREKKKKIL AERRKVLAID HLNEDQLREK AKELWQSIYN LEAEKFDLQE KFKQQKYEIN VLRNRINDNQ KVSKTRGKAK VTGRWK (1-285 aa encoded by B C002653)
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; TnTc; troponin T; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T2; troponin T2, cardiac; unnamed protein product
Gene Aliases: CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Human) 7139, (Rat) 24837, (Mouse) 21956
regulation of muscle contraction
striated muscle contraction
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
sarcomere organization
response to calcium ion
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
heart development
metabolic process
regulation of muscle filament sliding speed
protein heterooligomerization
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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