This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: RLALILCVTK AREGSEEDLD ALEHMFRQLR FESTMKRDPT AEQFQEELEK FQQAIDSRED PVSCAFVVLM AHGREGFLKG EDGEMVKLEN LFEALNNKNC QALRAKPKVY IIQACRGEQR DPGETVGGDE IVM
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 74%.
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-14 is a newly identified member of Caspase family. It has conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. It's high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptosis related cysteine protease; apoptosis-related cysteine protease; CASP-14; CASP14; Caspase 14; Caspase 14 apoptosis related cysteine protease; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase-14; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form
Gene Aliases: CASP14
UniProt ID: (Human) P31944
Entrez Gene ID: (Human) 23581