PA5-28969 targets Caspr2 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-28969 immunogen is recombinant fragment corresponding to a region within amino acids 287 and 633 of Human Caspr2.
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This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness.
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Protein Aliases: AUTS15; CASPR2; CDFE; Cell recognition molecule Caspr2; contactin-associated protein 2; Contactin-associated protein-like 2; homolog of Drosophila neurexin IV; NRXN4; PTHSL1
Gene Aliases: 5430425M22Rik; AUTS15; CASPR2; CDFE; CNTNAP2; KIAA0868; mKIAA0868; NRXN4; PTHSL1
Molecular Function: apolipoprotein cell adhesion molecule enzyme modulator extracellular matrix protein hydrolase membrane-bound signaling molecule metalloprotease oxidase oxidoreductase protease receptor serine protease signaling molecule transfer/carrier protein transporter