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Proteintech
Cathepsin B Polyclonal Antibody
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Product Details
12216-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cathepsin B Fusion Protein Ag2898 (1-339 aa encoded by BC010240)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MWQLWASLC CLLVLANARS RPSFHPVSDE LVNYVNKRNT TWQAGHNFYN VDMGYLKRLC GTFLGGPKPP QRVMFTEDLK LPASFDAREQ WPQCPTIKEI RDQGSCGSCW AFGAVEAISD RICIHTNAHV SVEVSAEDLL TCCGSMCGDG CNGGYPAEAW NFWTRKGLVS GGLYESHVGC RPYSIPPCEH HVNGSRPPCT GEGDTPKCSK ICEPGYSPTY KQDKHYGYNS YSVSNSEKDI MAEIYKNGPV EGAFSVYSDF LLYKSGVYQH VTGEMMGGHA IRILGWGVEN GTPYWLVANS WNTDWGDNGF FKILRGQDHC GIESEVVAGI PRTDQYWEKI (1-339 aa encoded by BC010240)
Target Information
Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; Cathepsin B1; cysteine protease
Gene Aliases: APPS; CB; CPSB; CTSB
UniProt ID: (Human) Q96D87, (Mouse) P10605
Entrez Gene ID: (Human) 1508, (Mouse) 13030
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
collagen binding
peptidase activity
cysteine-type peptidase activity
kininogen binding
peptide binding
proteoglycan binding
protein self-association
endopeptidase activity
hydrolase activity
protein complex binding
cysteine protease
toll-like receptor signaling pathway
proteolysis
autophagy
spermatogenesis
skeletal muscle tissue development
response to wounding
response to glucose
response to organic cyclic compound
response to amine
collagen catabolic process
epithelial cell differentiation
regulation of apoptotic process
response to peptide hormone
response to ethanol
decidualization
viral entry into host cell
regulation of catalytic activity
proteolysis involved in cellular protein catabolic process
negative regulation of cell death
response to interleukin-4
cellular response to mechanical stimulus
cellular response to thyroid hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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