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Invitrogen
Cathepsin D Polyclonal Antibody
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FIGURE: 1 / 6
Cathepsin D Antibody (PA5-79094) in ICC/IF
Immunofluorescence analysis of Cathepsin D was performed using 70% confluent log phase Neuro-2a cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Cathepsin D Polyclonal Antibody (Product # PA5-79094) at 1:100 in 0.1% BSA, incubated at 4 degree celsi... View More
Product Details
PA5-79094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived mouse Cathepsin D recombinant protein (Position: E65-L410).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Mouse Liver Tissue, Mouse Brain Tissue, Mouse Thymus Tissue, NEURO whole cell. IHC: Mouse Kidney tissue, Mouse Liver tissue, rat liver tissue.
Target Information
Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
Gene Aliases: CatD; CD; Ctsd
UniProt ID: (Mouse) P18242
Entrez Gene ID: (Mouse) 13033, (Rat) 171293
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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