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Invitrogen
Cathepsin D Polyclonal Antibody
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FIGURE: 1 / 4
Cathepsin D Antibody (PA5-72182) in ICC/IF
Immunocytochemistry analysis of Cathepsin D in MCF-7 cells. Samples were incubated with Cathepsin D polyclonal antibody (Product # PA5-72182) using a dilution of 1:25 followed by Dylight® 488-conjugated goat anti-Rabbit IgG at a dilution of 1:200 (green). Cells were 4% paraformaldehyde-fixed, 0. 1% Triton X-100 permeabilized. Immunofluorescence image showing cytoplasm staining on MCF-7 cell line. Cytoplasmi... View More
Product Details
PA5-72182
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between amino acids from human
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
120 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; ceroid-lipofuscinosis, neuronal 10; CTSD; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692; preprocathepsin D
Gene Aliases: CLN10; CPSD; CTSD; HEL-S-130P
UniProt ID: (Human) P07339
Entrez Gene ID: (Human) 1509
autophagosome assembly
proteolysis
antigen processing and presentation of exogenous peptide antigen via MHC class II
insulin receptor recycling
lipoprotein catabolic process
positive regulation of apoptotic process
regulation of establishment of protein localization
execution phase of apoptosis
insulin catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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