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          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Caveolin 1 Polyclonal Antibody

          View all (49) Caveolin 1 antibodies

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          Cite Caveolin 1 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (3)
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          Caveolin 1 Antibody (PA5-32689) in IHC (P)

          Immunohistochemistry analysis of Caveolin 1 in Human Brain, Cortex. Samples were incubated with Caveolin 1 polyclonal antibody (Product # PA5-32689). formalin-fixed paraffin-embedded . {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Polyclonal Antibody

          Product Details

          PA5-32689

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100
          -
          Product Specifications

          Species Reactivity

          Bat, Bovine, Dog, Horse, Guinea pig, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic 15 amino acid peptide from N-terminus of human CAV1 / Caveolin.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          50 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS

          Contains

          0.1% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2550152

          Product Specific Information

          Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Sheep, Bovine, Dog, Cat, Bat, Horse, Rabbit, Pig, Guinea pig (100%); Elephant, Armadillo (93%).

          For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: CAV1; caveolae; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; GIG32; HGNC:1527; membrane protein; OTTHUMP00000196475; unnamed protein product; Vesicular integral-membrane protein VIP21

          View more View less

          Gene Aliases: BSCL3; CAV; Cav-1; CAV1; CGL3; LCCNS; MSTP085; PPH3; VIP21

          View more View less

          UniProt ID: (Pig) Q6RVA9, (Rabbit) Q09YN6, (Bovine) P79132, (Sheep) Q6B3Y2, (Horse) Q2QLB0, (Human) Q03135, (Dog) P33724, (Mouse) P49817

          View more View less

          Entrez Gene ID: (Pig) 404693, (Rabbit) 100008837, (Bovine) 281040, (Sheep) 445468, (Horse) 100055975, (Human) 857, (Dog) 403980, (Mouse) 12389, (Rat) 25404, (Guinea pig) 100718512

          View more View less

          Function(s)
          receptor binding peptidase activator activity protein binding, bridging identical protein binding macromolecular complex binding protein heterodimerization activity Rac GTPase binding nitric-oxide synthase binding ATPase binding inward rectifier potassium channel inhibitor activity patched binding protein binding oxysterol binding cholesterol binding enzyme binding protein kinase binding protein tyrosine kinase inhibitor activity small GTPase binding nitric-oxide synthase inhibitor activity ion channel binding binding, bridging protein sequestering activity SNARE binding RNA polymerase I transcription factor binding structural molecule activity kinase binding syntaxin binding protein complex scaffold MDM2/MDM4 family protein binding scaffold/adaptor protein
          Process(es)
          biological_process negative regulation of transforming growth factor beta receptor signaling pathway T cell costimulation receptor internalization negative regulation of transcription from RNA polymerase II promoter inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of cytokine-mediated signaling pathway response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization response to bacterium positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of cholesterol efflux positive regulation of peptidase activity receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage regulation of blood coagulation positive regulation of cell migration negative regulation of epithelial cell differentiation negative regulation of protein ubiquitination positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation nitric oxide homeostasis positive regulation of toll-like receptor 3 signaling pathway insulin receptor internalization vasoconstriction negative regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis response to estrogen negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction negative regulation of pinocytosis negative regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity response to calcium ion membrane depolarization mammary gland involution positive regulation of cell adhesion molecule production negative regulation of necroptotic process cellular response to exogenous dsRNA cellular response to hyperoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of peptidyl-tyrosine autophosphorylation regulation of cell communication by electrical coupling involved in cardiac conduction positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of gap junction assembly negative regulation of inward rectifier potassium channel activity receptor internalization involved in canonical Wnt signaling pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway MAPK cascade endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of the force of heart contraction glandular epithelial cell differentiation nitric oxide biosynthetic process cellular calcium ion homeostasis cell proliferation negative regulation of cell proliferation cellular response to starvation negative regulation of signal transduction protein transport vesicle organization cytokine-mediated signaling pathway cell differentiation cholesterol transport negative regulation of BMP signaling pathway mammary gland development maintenance of protein location in cell toll-like receptor 4 signaling pathway regulation of toll-like receptor 4 signaling pathway angiotensin-activated signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade protein localization to plasma membrane raft nitric oxide metabolic process negative regulation of JAK-STAT cascade muscle cell cellular homeostasis fibroblast proliferation negative regulation of fibroblast proliferation regulation of cytosolic calcium ion concentration establishment of localization in cell calcium ion homeostasis canonical Wnt signaling pathway caveola assembly cellular response to misfolded protein cellular response to peptide hormone stimulus regulation of cardiac muscle cell action potential involved in regulation of contraction negative regulation of potassium ion transmembrane transport protein localization to basolateral plasma membrane positive regulation of ERAD pathway positive regulation of endothelial cell proliferation endocytosis response to mechanical stimulus positive regulation of signal transduction negative regulation of muscle cell apoptotic process positive regulation of microtubule polymerization cholesterol efflux wound healing negative regulation of tyrosine phosphorylation of Stat5 protein positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of neuron differentiation positive regulation of endocytosis microtubule polymerization negative regulation of smooth muscle cell proliferation protein oligomerization protein homooligomerization regulation of peptidase activity negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular senescence regulation of inward rectifier potassium channel activity negative regulation of cation channel activity response to nutrient response to gamma radiation organ regeneration response to drug response to glucocorticoid
          It has to be done as per old AB suggested Products section.

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