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Invitrogen
Cdc23 Recombinant Rabbit Monoclonal Antibody (R4G5)
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FIGURE: 1 / 1
Cdc23 Antibody (MA572224) in WB
Western blot analysis of Cdc23 in HeLa and K-562 lysates (25 µg/lane). Samples were incubated with Cdc23 Recombinant Monoclonal (Product # MA572224) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
Product Details
MA572224
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R4G5
Immunogen
KLH conjugated synthetic peptide derived from human Cdc23.
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Amount
75 µg
Purification
Protein A
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anaphase-promoting complex subunit 8; APC8; cell division cycle 23 homolog; Cell division cycle protein 23 homolog; Cyclosome subunit 8; tetratricopeptide protein; unnamed protein product
Gene Aliases: ANAPC8; APC8; CDC23; CUT23
UniProt ID: (Human) Q9UJX2
Entrez Gene ID: (Human) 8697
mitotic cell cycle
ubiquitin-dependent protein catabolic process
mitotic metaphase plate congression
metaphase/anaphase transition of mitotic cell cycle
regulation of exit from mitosis
regulation of mitotic cell cycle
protein ubiquitination
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
positive regulation of mitotic metaphase/anaphase transition
cell division
regulation of meiotic cell cycle
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein branched polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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