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Proteintech
Claudin 18 Polyclonal Antibody
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Product Details
21126-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Claudin 18 Fusion Protein Ag15517 (185-261 aa encoded by BC146668)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TLIGGVMMC IACRGLAPEE TNYKAVSYHA SGHSVAYKPG GFKASTGFGS NTKNKKIYDG GARTEDEVQS YPSKHDYV (185-261 aa encoded by BC146668)
Target Information
Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: claudin 18-like; Claudin-18; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; unnamed protein product
Gene Aliases: CLDN18; SFTA5; SFTPJ; UNQ778/PRO1572
UniProt ID: (Human) P56856, (Mouse) P56857, (Rat) Q5I0E5
Entrez Gene ID: (Human) 51208, (Mouse) 56492, (Rat) 315953
cell adhesion
negative regulation of tumor necrosis factor-mediated signaling pathway
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
protein localization to nucleus
organ growth
epithelial fluid transport
response to ethanol
negative regulation of bone resorption
lung alveolus development
digestive tract development
epithelial cell proliferation
bicellular tight junction assembly
cellular response to estrogen stimulus
tight junction organization
negative regulation of protein localization to nucleus
negative regulation of osteoclast development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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