PA5-28696 targets CoA synthase in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-28696 immunogen is recombinant fragment corresponding to a region within amino acids 256 and 564 of Human CoA synthase.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 188.8.131.52) and dephospho-CoA kinase (DPCK; EC 184.108.40.206), in prokaryotes (Daugherty et al., 2002 [PubMed 11923312]).
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Protein Aliases: Bifunctional coenzyme A synthase; bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; Coenzyme A synthase; Dephospho-CoA kinase; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; DPCK; DPCOAK; NBP; nucleotide binding protein; Pantetheine-phosphate adenylyltransferase; Phosphopantetheine adenylyltransferase; phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; POV-2; PPAT; UKR1
Gene Aliases: 1300003G02Rik; COASY; DPCK; NBIA6; NBP; pOV-2; PPAT; PSEC0106; UKR1