Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Human Cofilin shares 99% amino acid (aa) sequences identity with both mouse and rat Cofilin.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, monkey COS-7 whole cell, human HEK293 whole cell, human U-87MG whole cell, human HepG2 whole cell, human PC-3 whole cell, human THP-1 whole cell, human A549 whole cell, rat heart tissue, rat spleen tissue, rat lung tissue, rat C6 whole cell, mouse spleen tissue, mouse NIH/3T3 whole cell, mouse HEPA1-6 whole cell. IHC: mouse lung tissue, rat lung tissue, human intestinal cancer tissue, human mammary cancer tissue IHC-F: human placenta tissue. ICC/IF: U20S cell. Flow: U20S cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 18 kDa phosphoprotein; CFL-1; COF1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; Cofilin1; epididymis secretory protein Li 15; p18
Gene Aliases: AA959946; CFL; CFL1; Cof; cofilin; HEL-S-15; n-cofilin
UniProt ID: (Human) P23528, (Rat) P45592, (Mouse) P18760
Entrez Gene ID: (Human) 1072, (Rat) 29271, (Mouse) 12631
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