|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:5000-1:10,000|
|Tested Species reactivity||Bovine, Human, Mouse, Sheep, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Collagen type II from adult human knee cartilage and bovine nasal cartilage.|
|Purification||Antigen affinity chromatography|
|Storage buffer||BBS, pH 8.0, with 5mM EDTA|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-26206 detects Collagen II from bovine and human samples. PA1-26206 is expected to cross react with most mammals due to sequence homology. This antibody shows negligable cross reactivity with the Collagens 1, 3, 4, 5, and 6.
PA1-26206 has been successfully used in ELISA, Immunohistochemistry (P), immunoprecipitation, and Western blot procedures.
The PA1-26206 immunogen is Collagen type II from adult human knee cartilage and bovine nasal cartilage.
Store product at 4°C short term and -20°C after adding 50% glycerol.
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; Collagen 2; Collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen type II alpha 1 chain; collagen, type II, alpha 1; cyanogen bromide; disproportionate micromelia; pro-alpha 1(II); Procollagen II alpha 1; procollagen, type II, alpha 1; Type II Collagen
Gene Aliases: ANFH; AOM; BOS_5148; CB11; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COL2A1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856; SEDC; STL1
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