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Complement C3dg fragment Polyclonal Antibody

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Product Details

BS-4875R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Complement C3dg fragment.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; Complement C3; complement component 3; complement component C3a; complement component C3b; CRK SH3-binding GNRP; epididymis secretory sperm binding protein Li 62p; guanine nucleotide releasing factor 2; Guanine nucleotide-releasing factor 2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); HSE-MSF; prepro-C3; Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; Rap guanine nucleotide exchange factor 1; signal P; unnamed protein product

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Gene Aliases: 4932418O06Rik; AHUS5; AI255234; ARMD9; ASP; C3; C3a; C3b; C3G; C3G-1; C3G-2; CPAMD1; GRF2; HEL-S-62p; HSE-MSF; Plp; RAPGEF1

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UniProt ID: (Human) P01024, (Rat) P01026, (Mouse) P01027, (Human) Q13905

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Entrez Gene ID: (Human) 718, (Rat) 24232, (Mouse) 12266, (Human) 2889, (Rat) 63881, (Mouse) 107746

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Function(s)
antigen binding endopeptidase inhibitor activity receptor binding protein binding chemokine activity C5L2 anaphylatoxin chemotactic receptor binding receptor agonist activity lipid binding cofactor binding guanyl-nucleotide exchange factor activity SH3 domain binding Rap guanyl-nucleotide exchange factor activity signal transducer activity SH3/SH2 adaptor activity guanyl-nucleotide exchange factor protease inhibitor
Process(es)
positive regulation of type IIa hypersensitivity complement activation, lectin pathway activation of membrane attack complex positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process complement receptor mediated signaling pathway lipid metabolic process fatty acid metabolic process inflammatory response immune response complement activation complement activation, alternative pathway complement activation, classical pathway signal transduction G-protein coupled receptor signaling pathway opsonization response to bacterium positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling leukocyte chemotaxis killing of cells of other organism oviduct epithelium development B cell activation innate immune response positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of phagocytosis protein maturation positive regulation of phagocytosis, engulfment beta-amyloid clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning complement activation, GZMK pathway positive regulation of apoptotic cell clearance tolerance induction chemotaxis blood coagulation negative regulation of endopeptidase activity response to magnesium ion response to estradiol response to progesterone response to estrogen positive regulation of developmental growth response to glucocorticoid positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway small GTPase mediated signal transduction Ras protein signal transduction nervous system development positive regulation of neuron projection development Rap protein signal transduction nerve growth factor signaling pathway positive regulation of GTPase activity establishment of endothelial barrier cellular response to cAMP regulation of cell junction assembly cellular response to nerve growth factor stimulus blood vessel development single organismal cell-cell adhesion negative regulation of Ras protein signal transduction platelet-derived growth factor receptor signaling pathway regulation of small GTPase mediated signal transduction negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of canonical Wnt signaling pathway negative regulation of neural precursor cell proliferation positive regulation of signal transduction
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