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Bioss

Complement C3dg fragment Polyclonal Antibody

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Product Details

Applications
Tested Dilution
Publications
Western Blot (WB)
1:500-1:2,000
-
Immunohistochemistry (Paraffin) (IHC (P))
Assay-dependent
-
Immunofluorescence (IF)
Assay-dependent
-
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Complement C3dg fragment.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C

Target Information

The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acylation stimulating protein; acylation-stimulating protein cleavage product; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3-beta-c; C3a anaphylatoxin; C3adesArg; C3bc; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component C3a; complement component C3b; CRK SH3-binding GNRP; ENCF-1; ENCF-2; epididymis secretory sperm binding protein Li 62p; guanine nucleotide releasing factor 2; Guanine nucleotide-releasing factor 2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); HSE-MSF; Neutrophil chemotactic factor-1; Neutrophil chemotactic factor-2; prepro-C3; Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; Rap guanine nucleotide exchange factor 1

Gene Aliases: 4932418O06Rik; AHUS5; AI255234; ARMD9; ASP; C3; C3a; C3b; C3G; C3G-1; C3G-2; CPAMD1; GRF2; HEL-S-62p; HSE-MSF; Plp; RAPGEF1

UniProt ID: (Rat) P01026, (Human) P01024, (Mouse) P01027, (Human) Q13905

Entrez Gene ID: (Rat) 24232, (Human) 718, (Mouse) 12266, (Human) 2889, (Rat) 63881, (Mouse) 107746

Molecular Function: complement component cytokine defense/immunity protein enzyme modulator protease inhibitor serine protease inhibitor signaling molecule G-protein modulator guanyl-nucleotide exchange factor

Function(s)
positive regulation of type IIa hypersensitivity positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex tolerance induction fatty acid metabolic process chemotaxis inflammatory response complement activation complement activation, alternative pathway complement activation, classical pathway blood coagulation positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage negative regulation of endopeptidase activity response to magnesium ion response to estradiol response to progesterone response to estrogen positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of developmental growth positive regulation of phagocytosis response to glucocorticoid positive regulation of ERK1 and ERK2 cascade positive regulation of apoptotic cell clearance proteolysis immune response signal transduction G-protein coupled receptor signaling pathway regulation of complement activation regulation of immune response activation of MAPKK activity blood vessel development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of neuron projection development single organismal cell-cell adhesion Rap protein signal transduction nerve growth factor signaling pathway positive regulation of GTPase activity negative regulation of Ras protein signal transduction platelet-derived growth factor receptor signaling pathway negative regulation of protein kinase B signaling establishment of endothelial barrier negative regulation of ERK1 and ERK2 cascade cellular response to cAMP negative regulation of canonical Wnt signaling pathway regulation of cell junction assembly cellular response to nerve growth factor stimulus negative regulation of neural precursor cell proliferation small GTPase mediated signal transduction regulation of small GTPase mediated signal transduction positive regulation of signal transduction
Process(es)
endopeptidase inhibitor activity protein binding lipid binding C5L2 anaphylatoxin chemotactic receptor binding cofactor binding serine-type endopeptidase activity receptor binding Rap guanyl-nucleotide exchange factor activity SH3 domain binding guanyl-nucleotide exchange factor activity signal transducer activity SH3/SH2 adaptor activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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