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Invitrogen
Complement C5a Monoclonal Antibody (D2)
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FIGURE: 1 / 2
Complement C5a Antibody (MA5-43875) in WB
Western blot analysis of Complement C5a using Complement C5a Monoclonal Antibody (D2) (Product # MA5-43875) at a dilution of 0.5 µg/mL. Lane 1: Human Plasma; Lane 2: Rat Serum. Secondary antibody used is HRP-Goat anti-Mouse IgG polyclonal antibody at a dilution of 0.2 µg/mL.
Product Details
MA5-43875
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
D2
Immunogen
Recombinant C5a (Thr678-Arg751) expressed in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; C5a anaphylatoxin; CH; CO4; Complement C5; complement component 5; CPAMD3; DADB-112B14.11; FLJ17816; FLJ17822; FLJ60561; MGC142298; MGC164979; prepro-C5
Gene Aliases: C5; C5a; C5b; C5D; CPAMD4; ECLZB; Hc; RGD1561905
UniProt ID: (Human) P01031
Entrez Gene ID: (Rat) 362119, (Human) 727
in utero embryonic development
leukocyte migration involved in inflammatory response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
complement activation, alternative pathway
complement activation, classical pathway
positive regulation of vascular endothelial growth factor production
negative regulation of norepinephrine secretion
negative regulation of macrophage chemotaxis
negative regulation of dopamine secretion
glucose homeostasis
positive regulation of angiogenesis
positive regulation of chemotaxis
positive regulation of chemokine secretion
complement activation, lectin pathway
immune system process
regulation of immune system process
complement activation
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell migration
leukocyte chemotaxis
killing of cells of other organism
positive regulation of chemokine production
innate immune response
regulation of chemotaxis
cell chemotaxis
complement activation, GZMK pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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