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Invitrogen
Complement Factor B Monoclonal Antibody (9B8)
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Product Details
HYB 008-02-02
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
9B8
Immunogen
Factor B isolated from human plasma.
Conjugate
Form
Liquid
Concentration
0.98 mg/mL
Amount
196 µg
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
RRID
Product Specific Information
HYB 008-02-02 is specific for the Bb fragment of human factor B. Antibody binding abolishes the formation of C3bBb complexes.
HYB 008-02-02 has been successfully used in ELISA and Western blotting procedures. HYB 008-02-02 reacts strongly with factor B. Strong reaction is seen in sandwich ELISA in combination with a polyclonal antibody against factor B (e.g. DAKO A 343). In Western blotting after SDS-PAGE, HYB 008-02-02 reacts with the Bb fragment of factor B in non-reduced form only. After coupling to an activated CNBr-sepharose column, HYB 008-02-02 is suitable for affinity purification of human factor B.
The HYB 008-02-02 immunogen complement factor B isolated from human plasma.
Epitope specificity differs from that of HYB 008-06-02. Epitope specificity differs from that of HYB 008-04-02 and HAV 005-02-02 but slightly overlap as determined by inhibition ELISA.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
Factor B is a component of the alternative complement pathway. The protein is a single chain polypeptide with a molecular mass of 93 kDa. Factor B is cleaved by factor D into the Ba component (30 kDa) and the Bb (63 kDa). Bb together with C3b forms the alternative pathway C3 convertase C3bBb.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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