Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.
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Protein Aliases: Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5
Gene Aliases: 5730555N10Rik; Cnx40; Cx40; Cxn-40; Gja-5; Gja5
UniProt ID: (Mouse) Q01231
Entrez Gene ID: (Mouse) 14613
Molecular Function: gap junction