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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from an internal region of the mouse Connexin 40 (Cx40) protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
36-5000 was used in immunocytochemistry to study the effect of G9a histone methyltransferase inhibitor on bone marrow mesenchymal stem cells
|Yang J,Kaur K,Ong LL,Eisenberg CA,Eisenberg LM||Stem cells international (2015:null)||2015|
Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus.
36-5000 was used in immunocytochemistry to characterize connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus
|Bautista W,Rash JE,Vanderpool KG,Yasumura T,Nagy JI||The European journal of neuroscience (39:757)||2014|
Contribution of intracellular calcium and pH in ischemic uncoupling of cardiac gap junction channels formed of connexins 43, 40, and 45: a critical function of C-terminal domain.
36-5000 was used in immunocytochemistry to examine the vulnerability of different cardiac gap junction channels formed of connexins 43, 40, and 45 to simulated ischemia.
|Sahu G,Bera AK||PloS one (8:null)||2013|
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
36-5000 was used in western blot to demonstrate that HACE protects the heart under pressure stress by regulating protein degradation.
|Zhang L,Chen X,Sharma P,Moon M,Sheftel AD,Dawood F,Nghiem MP,Wu J,Li RK,Gramolini AO,Sorensen PH,Penninger JM,Brumell JH,Liu PP||Nature communications (5:null)||2014|
|Human||1:200||Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality.||Wang HX,Tong D,El-Gehani F,Tekpetey FR,Kidder GM||Journal of cellular and molecular medicine (13:972)||2009|
||Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality.||Wang HX,Tong D,El-Gehani F,Tekpetey FR,Kidder GM||Journal of cellular and molecular medicine (13:972)||2009|
ATFB11; Connexin-40; CX40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; GJA5
5730555N10Rik; Cnx40; Cx40; Cxn-40; Gja-5; Gja5