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Invitrogen

Connexin 40 Polyclonal Antibody

View all (9) Connexin 40 antibodies

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Connexin 40 Polyclonal Antibody

Product Details

PA5149613

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GJA5
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3709601

Product Specific Information

Immunogen sequence: KKIRQRFVKP RQHMAKCQLS GPSVGIVQSC TPPPDFNQCL ENGPGGKFFN PFSNNMASQQ NTDNLVTEQV RGQEQTPG

Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 62%.

Target Information

Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: connexin 40; Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction protein alpha 5 40kDa

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Gene Aliases: ATFB11; CX40; GJA5

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UniProt ID: (Human) P36382

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Entrez Gene ID: (Human) 2702

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Function(s)
gap junction channel activity protein binding gap junction hemi-channel activity connexin binding gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling gap junction channel activity involved in cardiac conduction electrical coupling gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling disordered domain specific binding
Process(es)
skeletal system development angiogenesis blood vessel development renal system process involved in regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure negative regulation of glomerular filtration outflow tract morphogenesis endothelium development cardiac conduction system development mitral valve development pulmonary valve formation ventricular septum development atrial septum development septum primum development atrial ventricular junction remodeling potassium ion transport cell communication cell-cell signaling heart development cell communication by chemical coupling cell communication by electrical coupling regulation of cell communication by electrical coupling positive regulation of cell communication by chemical coupling gap junction assembly embryonic limb morphogenesis embryonic heart tube development foramen ovale closure vasodilation negative regulation of blood pressure positive regulation of vasoconstriction artery morphogenesis transmembrane transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization ventricular septum morphogenesis atrial septum morphogenesis cardiac conduction ventricular cardiac muscle cell action potential SA node cell action potential SA node cell to atrial cardiac muscle cell communication by electrical coupling atrial cardiac muscle cell to AV node cell communication by electrical coupling AV node cell to bundle of His cell communication by electrical coupling bundle of His cell to Purkinje myocyte communication by electrical coupling Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction regulation of blood vessel diameter regulation of AV node cell action potential regulation of bundle of His cell action potential regulation of Purkinje myocyte action potential regulation of atrial cardiac muscle cell action potential regulation of renin secretion into blood stream regulation of membrane depolarization during cardiac muscle cell action potential vasomotion
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