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Product Details
22717-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Connexin-46 Fusion Protein Ag18580 (223-435 aa encoded by BC121137) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.34 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: YHLGWKKLK QGVTSRLGPD ASEAPLGTAD PPPLPPSSRP PAVAIGFPPY YAHTAAPLGQ ARAVGYPGAP PPAADFKMLA LTEARGKGQS AKLYNGHHHL LMTEQNWANQ AAERQPPALK AYPAASTPAA PSPVGSSSPP LAHEAEAGAA PLLLDGSGSS LEGSALAGTP EEEEQAVTTA AQMHQPPLPL GDPGRASKAS RASSGRARPE DLAI (223-435 aa encoded by B C121137)
Target Information
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: connexin 46; Connexin-46; Cx46; gap junction alpha 3; Gap junction alpha-3 protein; gap junction protein, alpha 3, 46kDa
Gene Aliases: CTRCT14; CX46; CZP3; GJA3
UniProt ID: (Human) Q9Y6H8
Entrez Gene ID: (Human) 2700
Molecular Function:
gap junction
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