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Invitrogen
Cripto Polyclonal Antibody, DyLight™ 650
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Product Details
PA5-22699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an N-terminal portion of mouse Cripto1 (between residues 1-50).
Conjugate
Excitation/Emission Max
651/673 nm
View spectra
Form
Liquid
Concentration
0.94 mg/mL
Amount
94 µg
Purification
Antigen affinity chromatography
Storage buffer
50mM sodium borate
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blot a band is seen at ~18 kDa representing the core form of Cripto1, and at ~36 kDa reporesenting the glycosylated/ post-translationally modified form.
Suggested positive control: MDA-MB231 (human breast cancer) lysates.
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRGF; Cripto growth factor; Cripto, EGF-CFC family member; Cripto-1; Cripto-1 growth factor; Cripto-3; Epidermal growth factor-like Cripto protein; Epidermal growth factor-like cripto protein CR1; Protein Cripto; TDGF2; Teratocarcinoma-derived growth factor; Teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR); unnamed protein product
Gene Aliases: CR; CR-1; CR1; CRGF; CRIPTO; CRIPTO-1; TDGF1
UniProt ID: (Human) P13385, (Mouse) P51865
Entrez Gene ID: (Human) 6997, (Mouse) 21667
blood vessel development
morphogenesis of a branching structure
cell migration involved in sprouting angiogenesis
signal transduction
epidermal growth factor receptor signaling pathway
determination of left/right symmetry
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
embryo development ending in birth or egg hatching
anterior/posterior pattern specification
regulation of signal transduction
positive regulation of endothelial cell migration
cell differentiation
positive regulation of cell migration
mammary gland development
cellular response to hepatocyte growth factor stimulus
nodal signaling pathway
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
cellular response to fibroblast growth factor stimulus
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
activation of MAPK activity
vasculogenesis
in utero embryonic development
positive regulation of cell-matrix adhesion
gastrulation
anterior/posterior axis specification
peptidyl-serine phosphorylation
regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
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