PA5-16237 targets Cyclin E in IF, IP, and WB applications and shows reactivity with mouse and Human samples.
The PA5-16237 immunogen is a synthetic peptide derived from the C-terminus of human cyclin E.
Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
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Protein Aliases: cyclin Es; cyclin Et; G1/S-specific cyclin-E1
Gene Aliases: AW538188; CCNE; CCNE1; CycE1; pCCNE1