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Cyclooxygenase 1 Polyclonal Antibody
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FIGURE: 1 / 1
Cyclooxygenase 1 Antibody (BS-0582R) in WB
Lane 1: NIH/3T3 lysates; Lane 2: Hela lysates; Lane 3: Huvec lysates probed with Cyclooxygenase 1 Polyclonal Antibody, Unconjugated (bs-0582R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.
Product Details
BS-0582R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from rat Cyclooxygenase 1, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COX-1; COX-1b1; COX-1b2; COX-1b3; cyclooxygenase 3; Cyclooxygenase-1; P PGG/HS; PGH synthase 1; PHS 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); unnamed protein product
Gene Aliases: Cox-1; Cox-3; COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219, (Mouse) P22437
Entrez Gene ID: (Human) 5742, (Rat) 24693, (Mouse) 19224
peroxidase activity
prostaglandin-endoperoxide synthase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
heme binding
metal ion binding
dioxygenase activity
lipid binding
oxygenase
prostaglandin biosynthetic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
response to oxidative stress
regulation of blood pressure
cyclooxygenase pathway
regulation of cell proliferation
cellular oxidant detoxification
inflammatory response
aging
learning
memory
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
keratinocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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