Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with Papain and the cathepsins B, H and L. Cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.
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Protein Aliases: CPI-B; cystatin B (stefin B); Cystatin-B; Liver thiol proteinase inhibitor; stefin B; Stefin-B
Gene Aliases: CPI-B; CST6; CSTB; EPM1; EPM1A; PME; STFB; ULD
UniProt ID: (Human) P04080
Entrez Gene ID: (Human) 1476
Molecular Function: protease inhibitor