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Cystatin-C Polyclonal Antibody
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FIGURE: 1 / 2
Cystatin-C Antibody (BS-10876R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with Cystatin-C Polyclonal Antibody, Unconjugated (bs-10876R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-10876R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant human Cystatin-C
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cystatin C, a member of the type 2 cystatin superfamily, is a potent inhibitor of cysteine proteinases, both endogenous (lysosomal cathepsins), and pathogenic. Cystatin C is a 13 kDa secreted protein which is found in high concentrations in biological fluids and is thought to be expressed by all human nucleated cells. Changes in Cystatin C have been documented in a number of cardiovascular diseases, including atherosclerosis, amyloid angiopathy and myocardial infarction. Its low molecular weight also means that Cystatin C can be used as a marker of renal failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD8; bA218C14.4 (cystatin C); CST3; cystatin 3; Cystatin C (cysteine proteinase inhibitor); Cystatin-3; Cystatin-C; Cystatin3; CystatinC; epididymis secretory protein Li 2; Gamma-trace; MGC117328; Neuroendocrine basic polypeptide; OTTHUMP00000030440; OTTHUMP00000164181; OTTHUMP00000164182; OTTMUSP00000016736; Post-gamma-globulin; RP23-250M11.9; unnamed protein product
Gene Aliases: ADLDWA; ARMD11; CST3; CYSC; HEL-S-2
UniProt ID: (Human) P01034, (Mouse) P21460, (Rat) P14841
Entrez Gene ID: (Human) 1471, (Mouse) 13010, (Rat) 25307
defense response
response to oxidative stress
positive regulation of cell proliferation
negative regulation of peptidase activity
negative regulation of endopeptidase activity
regulation of programmed cell death
extracellular fibril organization
positive regulation of DNA replication
negative regulation of proteolysis
negative regulation of elastin catabolic process
negative regulation of cell death
eye development
response to hypoxia
cell activation
apoptotic process
brain development
salivary gland development
embryo implantation
male gonad development
response to toxic substance
response to carbohydrate
response to inorganic substance
negative regulation of collagen catabolic process
negative regulation of extracellular matrix disassembly
response to organic cyclic compound
response to nutrient levels
response to estradiol
regulation of tissue remodeling
cellular response to oxidative stress
response to drug
circadian sleep/wake cycle, REM sleep
response to axon injury
Sertoli cell development
negative regulation of blood vessel remodeling
cellular response to hydrogen peroxide
immune response
fibril organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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