45-6100 was used successfully in the western blot analysis of cytochrome C using human breast cancer cell line lysates. |Positive control: Isolated mitochondria from Human, Bovine, Rat and Mouse heart; Human fibroblasts; HeLa cells.
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
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Protein Aliases: CYC; Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; HCS; THC4
Gene Aliases: BOS_4320; CYC; CYCS; CYCSA; cytc; HCS; THC4