Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Cytokeratin 8 Fusion Protein Ag0488 (1-483 aa encoded by BC000654) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MSIRVTQKS YKVSTSGPRA FSSRSYTSGP GSRISSSSFS RVGSSNFRGG LGGGYGGASG MGGITAVTVN QSLLSPLVLE VDPNIQAVRT QEKEQIKTLN NKFASFIDKV RFLEQQNKML ETKWSLLQQQ KTARSNMDNM FESYINNLRR QLETLGQEKL KLEAELGNMQ GLVEDFKNKY EDEINKRTEM ENEFVLIKKD VDEAYMNKVE LESRLEGLTD EINFLRQLYE EEIRELQSQI SDTSVVLSMD NSRSLDMDSI IAEVKAQYED IANRSRAEAE SMYQIKYEEL QSLAGKHGDD LRRTKTEISE MNRNISRLQA EIEGLKGQRA SLEAAIADAE QRGELAIKDA NAKLSELEAA LQRAKQDMAR QLREYQELMN VKLALDIEIA TYRKLLEGEE SRLESGMQNM SIHTKTTSGY AGGLSSAYGG LTSPGLSYSL GSSFGSGAGS SSFSRTSSSR AVVVKKIETR DGKLVSESSD VLPK (1-483 aa encoded by BC000654)
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C CY K2C8; CK 8; CK-8; cytokeratin 8; Cytokeratin endo A; Cytokeratin-8; hard keratin; K-8; K8; keratin 8, type II; keratin complex 2, basic, gene 8; Keratin, type II cytoskeletal 8; Keratin-8; Type-II keratin Kb8
Gene Aliases: AA960620; AL022697; AU019895; CARD2; CK-8; CK8; CYK8; CYKER; EndoA; K2C8; K8; KO; Krt-2.8; Krt2-8; KRT8
UniProt ID: (Human) P05787, (Mouse) P11679, (Rat) Q10758
Entrez Gene ID: (Human) 3856, (Mouse) 16691, (Rat) 25626
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