This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Immunogen sequence: NAFSANLNFF PTPNPDPFRD DPFTQPDQST PSSFDSLKSP DQKKENSSSS STPLSNGPLN GDVDYFGQQF DQISNRTGKQ EAQAGPWPFS SSQTQPAVRT QNGVSEREQN GFSVKSSPNP
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 82%.
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adaptor molecule disabled-2; Dab, mitogen-responsive phosphoprotein, homolog 2; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; DOC-2; FLJ26626
Gene Aliases: DAB2; DOC-2; DOC2
UniProt ID: (Human) P98082
Entrez Gene ID: (Human) 1601
Molecular Function: scaffold/adaptor protein