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Proteintech
DAB2IP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
23582-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DAB2IP Fusion Protein Ag20308 (523-700 aa encoded by BC146762)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.72 mg/mL
Amount
108 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RDVHTALST PGSGQLPGTN DLASTPGSGS SSISAGLQKM VIENDLSGLI DFTRLPSPTP ENKDLFFVTR SSGVQPSPAR SSSYSEANEP DLQMANGGKS LSMVDLQDAR TLDGEAGSPA GPDVLPTDGQ AAAAQLVAGW PARATPVNLA GLATVRRAGQ TPTTPGTSEG APGRPQLLA (523-700 aa encoded by BC146762)
Target Information
DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ASK-interacting protein 1; ASK1-interacting protein 1; DAB2 interaction protein; DAB2-interacting protein; disabled 2 interacting protein long form; DOC-2/DAB-2 interactive protein; DOC-2/DAB2 interactive protein; MLL fusion partner; nGAP-like protein; ras GTPase activating protein; Ras-GTPase activating protein; RasGAP; unnamed protein product
Gene Aliases: 2310011D08Rik; AF9Q34; AIP-1; AIP1; DIP1/2; mKIAA1743
UniProt ID: (Human) Q5VWQ8, (Mouse) Q3UHC7
Entrez Gene ID: (Human) 153090, (Mouse) 69601
GTPase activator activity
death receptor binding
protein binding
SH3 domain binding
kinase binding
protein kinase binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
phosphatidylinositol-3-phosphate binding
signaling adaptor activity
Toll-like receptor 4 binding
phosphatidylinositol 3-kinase regulatory subunit binding
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 2 binding
protein serine/threonine kinase activator activity
phosphatidylinositol 3-kinase binding
macromolecular complex binding
cadherin binding
protein phosphatase 2A binding
phosphatidylinositol-4-phosphate binding
14-3-3 protein binding
negative regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell migration
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
positive regulation of neuron projection development
negative regulation of angiogenesis
cell motility involved in cerebral cortex radial glia guided migration
layer formation in cerebral cortex
protein catabolic process
negative regulation of cell growth
negative regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of protein complex assembly
tumor necrosis factor-mediated signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of GTPase activity
tube formation
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of apoptotic process
regulation of GTPase activity
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of MAPK cascade
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of Ras protein signal transduction
negative regulation of fibroblast proliferation
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
regulation of cell cycle
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of G0 to G1 transition
negative regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
negative regulation of canonical Wnt signaling pathway
positive regulation of synapse maturation
lipid droplet formation
positive regulation of dendrite development
regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of NIK/NF-kappaB signaling
positive regulation of proteasomal protein catabolic process
regulation of intracellular signal transduction
positive regulation of neuron migration
positive regulation of apoptotic signaling pathway
cellular response to unfolded protein
endothelial cell apoptotic process
positive regulation of IRE1-mediated unfolded protein response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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