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Invitrogen
DAB2IP Polyclonal Antibody
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Product Details
PA5-85697
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human DAB2IP. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.06 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (98%), Bovine (98%).
Positive Control: 293T, A431, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AIP-1; ASK-interacting protein 1; ASK1-interacting protein 1; DAB2 interaction protein; Disabled homolog 2-interacting protein; DOC-2/DAB-2 interactive protein; DOC-2/DAB2 interactive protein; nGAP-like protein
Gene Aliases: AF9Q34; AIP-1; AIP1; DAB2IP; DIP1/2; KIAA1743
UniProt ID: (Human) Q5VWQ8
Entrez Gene ID: (Human) 153090
GTPase activator activity
death receptor binding
protein binding
SH3 domain binding
kinase binding
protein kinase binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
phosphatidylinositol-3-phosphate binding
protein complex binding
signaling adaptor activity
Toll-like receptor 4 binding
phosphatidylinositol 3-kinase regulatory subunit binding
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 2 binding
phosphatidylinositol 3-kinase binding
protein phosphatase 2A binding
phosphatidylinositol-4-phosphate binding
14-3-3 protein binding
cadherin binding involved in cell-cell adhesion
GTPase-activating protein
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPKKK activity
angiogenesis
negative regulation of protein phosphorylation
inflammatory response
activation of signaling protein activity involved in unfolded protein response
cell cycle
I-kappaB phosphorylation
activation of JUN kinase activity
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell migration
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
positive regulation of neuron projection development
negative regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
cell motility involved in cerebral cortex radial glia guided migration
layer formation in cerebral cortex
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of GTPase activity
tube formation
negative regulation of catenin import into nucleus
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
reelin-mediated signaling pathway
regulation of growth
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
regulation of GTPase activity
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of MAP kinase activity
positive regulation of MAPK cascade
regulation of protein heterodimerization activity
positive regulation of JUN kinase activity
positive regulation of GTPase activity
negative regulation of phosphatidylinositol 3-kinase activity
cellular protein catabolic process
innate immune response
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of Ras protein signal transduction
negative regulation of fibroblast proliferation
neuron projection morphogenesis
negative regulation of epithelial cell proliferation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of G0 to G1 transition
negative regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle arrest
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
negative regulation of protein serine/threonine kinase activity
positive regulation of protein serine/threonine kinase activity
endothelial cell apoptotic process
negative regulation of canonical Wnt signaling pathway
positive regulation of synapse maturation
cell-cell adhesion
positive regulation of dendrite development
regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of proteasomal protein catabolic process
positive regulation of IRE1-mediated unfolded protein response
negative regulation of cyclin catabolic process
positive regulation of neuron migration
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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