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Product Details
PA5-145046
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 523-580. Recombinant protein control fragment (Product #RP-110099).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091795
Product Specific Information
Immunogen sequence: TESSSDRIPV HQNGLSMNQM LMGLSPNVLP GPKEGDLAGH DMGHESKRMH IEKDETPL
Antigen sequence identity: Mouse 98%; Rat 98%
Target Information
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dac homolog; Dach1; Dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
Gene Aliases: DACH; DACH1
UniProt ID: (Human) D0FY35
Entrez Gene ID: (Human) 1602
transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
suckling behavior
multicellular organism development
respiratory gaseous exchange
cell proliferation
negative regulation of transcription by competitive promoter binding
negative regulation of cell migration
regulation of nuclear cell cycle DNA replication
negative regulation of transcription, DNA-templated
development of primary female sexual characteristics
negative regulation of fibroblast proliferation
RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of cell proliferation involved in contact inhibition
negative regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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