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Invitrogen
DAPK2 Polyclonal Antibody
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FIGURE: 1 / 4
DAPK2 Antibody (PA5-14045) in IHC (P)
Immunohistochemistry analysis of DAPK2 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with DAPK2 polyclonal antibody (Product # PA5-14045) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
Product Details
PA5-14045
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 40-70 amino acids from the N-terminal region of human DAPK2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
DAPK2 is a calcium/calmodulin-dependent kinase that acts as a positive regulator of apoptosis, and is expressed in many tissue types. DAPK2 encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 2; DAP-kinase-related protein 1; DAP-kinase-related protein 1 beta isoform; death-associated kinase 2; Death-associated protein kinase 2; DRAK2; DRP-1; MGC119312
Gene Aliases: DAPK2; DRP-1; DRP1
UniProt ID: (Human) Q9UIK4, (Mouse) Q8VDF3
Entrez Gene ID: (Human) 23604, (Mouse) 13143
protein serine/threonine kinase activity
protein binding
calmodulin binding
ATP binding
identical protein binding
nucleotide binding
protein kinase activity
calmodulin-dependent protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
immunoglobulin
protein phosphorylation
apoptotic process
regulation of autophagy
intracellular signal transduction
regulation of apoptotic process
anoikis
protein autophosphorylation
positive regulation of neutrophil chemotaxis
neutrophil migration
positive regulation of eosinophil chemotaxis
regulation of intrinsic apoptotic signaling pathway
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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