Immunogen sequence: MLFRLSEHSS PEEEASPHQR ASGEGHHLKS KRPNPCAYTP PSLKAVQRIA ESHLQSISNL NENQASEEED ELGELRELGY PREEDEEEEE DDEEEEEEED SQAEVLKVIR QSAGQKTTCG QGLEGPWERP PPLDESERDG GSEDQVEDPA LSEPGEEPQR PSPSEPGT; Positive Samples: 293T; Cellular Location: Cytoplasm
DARPP-32 is a dopamine (DA) and AMP-regulated approximately 32 kDa phosphoprotein that is associated with dopaminoceptive neurons. The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac.
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Protein Aliases: DARPP-32; dopamine and cAMP-regulated neuronal phosphoprotein 32; Dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; Protein phosphatase 1 regulatory subunit 1B
Gene Aliases: AU040756; DARPP-32; DARPP32; PPP1R1B