Proteintech

DARS2 Polyclonal Antibody

DARS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DARS2 Antibody (13807-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 13807-1-AP (DARS2 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

13807-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DARS2 Fusion Protein Ag4809 (296-645 aa encoded by BC045173)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LIEGLLQYS WPNDKDPVVV PFPTMTFAEV LATYGTDKPD TRFGMKIIDI SDVFRNTEIG FLQDALSKPH GTVKAICIPE GAKYLKRKDI ESIRNFAADH FNQEILPVFL NANRNWNSPV ANFIMESQRL ELIRLMETQE EDVVLLTAGE HNKACSLLGK LRLECADLLE TRGVVLRDPT LFSFLWVVDF PLFLPKEENP RELESAHHPF TAPHPSDIHL LYTEPKKARS QHYDLVLNGN EIGGGSIRIH NAELQRYILA TLLKEDVKML SHLLQALDYG APPHGGIALG LDRLICLVTG SPSIRDVIAF PKSFRGHDLM SNTPDSVPPE ELKPYHIRVS KPTDSKAERA H (296-645 aa encoded by BC045173)

Target Information

The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.

Cell metabolism

Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA

Tue Dec 07 00:00:00 UTC 2021

Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model.

The international journal of biochemistry & cell biology

Hunter CA,Kartal F,Koc ZC,Murphy T,Kim JH,Denvir J,Koc EC

Fri Nov 01 00:00:00 UTC 2019

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.

EMBO reports

Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A

Fri Jul 01 00:00:00 UTC 2016

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.

EMBO reports

Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A

Fri Jul 01 00:00:00 UTC 2016

Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.

Cell metabolism

Dogan SA,Pujol C,Maiti P,Kukat A,Wang S,Hermans S,Senft K,Wibom R,Rugarli EI,Trifunovic A

Tue Mar 04 00:00:00 UTC 2014

Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.

Cell metabolism

Dogan SA,Pujol C,Maiti P,Kukat A,Wang S,Hermans S,Senft K,Wibom R,Rugarli EI,Trifunovic A

Tue Mar 04 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: aspartate tRNA ligase 2, mitochondrial; Aspartate--tRNA ligase, mitochondrial; Aspartyl-tRNA synthetase; aspartyl-tRNA synthetase, mitochondrial; AspRS

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Gene Aliases: 5830468K18Rik; ASPRS; DARS2; LBSL; MT-ASPRS; RGD1308286

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UniProt ID: (Human) Q6PI48, (Rat) Q3KRD0, (Mouse) Q8BIP0

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Entrez Gene ID: (Human) 55157, (Rat) 304919, (Mouse) 226539

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Function(s)

tRNA binding aspartate-tRNA ligase activity protein binding ATP binding protein homodimerization activity aspartate-tRNA(Asn) ligase activity nucleic acid binding nucleotide binding aminoacyl-tRNA ligase activity ligase activity aminoacyl-tRNA synthetase

Process(es)

tRNA aminoacylation for protein translation tRNA aminoacylation mitochondrial asparaginyl-tRNA aminoacylation translation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DARS2 Polyclonal Antibody

DARS2 Antibody (13807-1-AP) in IHC (P)

Product Details

13807-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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