Immunogen sequence: ENNMQAEVTG KLKQHFNNAL PKQNSTTTGV SVIMNTALDK EGQIFCSKHC QDSGRPGMEP ISPVPPSVEE IPVPGEAVPA PTPPESPTPH CPPAAPGGER AG
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
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Protein Aliases: CaMK-like CREB regulatory kinase 2; CL2; DCAMKL2; DCDC3; DCDC3B; DCK2; doublecortin and CaM kinase-like 2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; MGC45428; Serine/threonine-protein kinase DCLK2
Gene Aliases: CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2
UniProt ID: (Human) Q8N568
Entrez Gene ID: (Human) 166614
Molecular Function: non-receptor serine/threonine protein kinase