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Product Details
11747-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DCLRE1C Fusion Protein Ag2343 (1-325 aa encoded by BC022254)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: MSSFEGQMA EYPTISIDRF DRENLRARAY FLSHCHKDHM KGLRAPTLKR RLECSLKVYL YCSPVTKELL LTSPKYRFWK KRIISIEIET PTQISLVDEA SGEKEEIVVT LLPAGHCPGS VMFLFQGNNG TVLYTGDFRL AQGEAARMEL LHSGGRVKDI QSVYLDTTFC DPRFYQIPSR EECLSGVLEL VRSWITRSPY HVVWLNCKAA YGYEYLFTNL SEELGVQVHV NKLDMFRNMP EILRHLTTDR NTQIHACRHP KAEEYFQWSK LPCGITSRNR IPLHIISIKP STMWFGERSR KTNVIVRTGE SSYRACFSFH SSYSEI (1-325 aa encoded by B C022254)
Target Information
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DCLRE1C protein; DNA cross-link repair 1A, PSO2 homolog; DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1C protein; FLJ11360; hSNM1C; mArt; Protein A-SCID; Protein artemis; RS SCID; severe combined immunodeficiency, type a (Athabascan); SNM1 homolog C; SNM1-like protein; SNM1C antibody; tein
Gene Aliases: 9930121L06Rik; A-SCID; AI661365; Art; ARTEMIS; ASCID; DCLRE1C; DCLREC1C; RS-SCID; SCIDA; SNM1C; Snm1l
UniProt ID: (Human) Q96SD1, (Mouse) Q8BG72, (Rat) Q5XIX3
Entrez Gene ID: (Human) 64421, (Mouse) 227525, (Rat) 259171
Molecular Function:
DNA metabolism protein
adaptive immune response
double-strand break repair via nonhomologous end joining
response to ionizing radiation
B cell differentiation
protection from non-homologous end joining at telomere
V(D)J recombination
interstrand cross-link repair
nucleic acid phosphodiester bond hydrolysis
telomere maintenance
immune system process
DNA metabolic process
DNA repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
chromosome organization
DNA catabolic process, endonucleolytic
biological_process
single-stranded DNA endodeoxyribonuclease activity
damaged DNA binding
endonuclease activity
protein binding
5'-3' exonuclease activity
5'-3' exodeoxyribonuclease activity
nuclease activity
exonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
molecular_function
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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