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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 129 and 337 of Human DCPS|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30532 targets DCPS in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30532 immunogen is recombinant fragment corresponding to a region within amino acids 129 and 337 of Human DCPS.
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase; DCS-1; Decapping scavenger enzyme; heat shock-like protein 1; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; HSL1; m7GpppX diphosphatase; mRNA decapping enzyme; Scavenger mRNA-decapping enzyme DcpS
ARS; DCPS; DCS1; HINT-5; HINT5; HSL1; HSPC015