Search
Proteintech
DDX21 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
10528-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DDX21 Fusion Protein Ag0804 (1-180 aa encoded by BC008071)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
64.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
DDX21 exists as two isoforms, molecular weight of modified isoform one is about 87 -100 kDa, and the post-modified isoform is about 75-85 kDa. 10528-1-AP is a rabbit polyclonal antibody raised against the N-terminal of human DDX21.
Immunogen sequence: MPGKLRSDA GLESDTAMKK GETLRKQTEE KEKKEKPKSD KTEEIAEEEE TVFPKAKQVK KKAEPSEVDM NSPKSKKAKK KEEPSQNDIS PKTKSLRKKK EPIEKKVVSS KTKKVTKNEE PSEEEIDAPK PKKMKKEKEM NGETREKSPK LKNGFPHPEP DCNPSEAASE ESNSEIEQEI P (1-180 aa encoded by BC008071)
Target Information
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DEAD (Asp-Glu-Ala-Asp) box helicase 21; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a; DEAD box protein 21; DEAD-box helicase 21; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu); Gu protein; Gu-alpha; Nucleolar RNA helicase 2; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu; RH-II/Gualpha; RNA helicase II/Gu alpha; unnamed protein product
Gene Aliases: AI255159; AL022742; D10Ertd645e; D10Wsu42e; DDX21; Ddx21a; gu-alpha; GUA; GURDB; II/Gu; RH; RH II/Gu; RH-II/GU; RH-II/GuA
UniProt ID: (Human) Q13436, (Rat) Q3B8Q1, (Mouse) Q9JIK5
Entrez Gene ID: (Human) 9188, (Rat) 317399, (Mouse) 56200
nucleotide binding
nucleic acid binding
RNA binding
RNA helicase activity
double-stranded RNA binding
mRNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
rRNA binding
snoRNA binding
miRNA binding
identical protein binding
7SK snRNA binding
RNA polymerase inhibitor activity
poly(A) RNA binding
ATP-dependent RNA helicase activity
osteoblast differentiation
metabolic process
response to virus
response to exogenous dsRNA
immune system process
positive regulation of myeloid dendritic cell cytokine production
chromatin remodeling
rRNA processing
transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of macromolecule biosynthetic process
negative regulation of transcription from RNA polymerase I promoter
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
defense response to virus
R-loop processing
transcription, DNA-templated
RNA secondary structure unwinding
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support