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DENND4C is guanine nucleotide exchange factor (GEF) activating RAB10. It promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
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Protein Aliases: DENN domain-containing protein 4C; DENN/MADD domain containing 4A pseudogene; DENN/MADD domain containing 4C; likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)
Gene Aliases: 1700065A05Rik; AA420392; bA513M16.3; C9orf55; C9orf55B; DENND4C; RAB10GEF; RGD1308489
UniProt ID: (Human) Q5VZ89, (Mouse) A6H8H2
Entrez Gene ID: (Human) 55667, (Mouse) 329877, (Rat) 313340
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