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DEPTOR Polyclonal Antibody
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FIGURE: 1 / 4
DEPTOR Antibody (BS-8255R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human colon cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with DEPTOR Polyclonal Antibody, Unconjugated (bs-8255R) at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB stainin... View More
Product Details
BS-8255R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6, amino acids 56-170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DEPDC6 is a gene that encodes a protein known for its role in various cellular processes, although the specifics of its function remain not fully elucidated. Located on chromosome 22, DEPDC6 is involved in regulating cell growth and survival by modulating the RAS signaling pathway, a crucial pathway for many cellular functions. Structurally, DEPDC6 contains a DEP domain, which is known to mediate interactions with other proteins that are involved in signal transduction. This domain plays a significant role in facilitating the proper localization and function of the protein. Functionally, DEPDC6 is implicated in controlling the pathways that govern the timing and progression of the cell cycle, highlighting its importance in maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Its dysregulation has been associated with various cancers, emphasizing the need for further studies to fully understand its potential as a therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DEP domain containing 6; DEP domain containing MTOR-interacting protein; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; hDEPTOR; unnamed protein product
Gene Aliases: DEP.6; DEPDC6; DEPTOR; hDEPTOR; Kiaa4200; RGD1561030
UniProt ID: (Human) Q8TB45, (Mouse) Q570Y9
Entrez Gene ID: (Human) 64798, (Mouse) 97998, (Rat) 314979
autophagosome assembly
negative regulation of protein kinase activity
G-protein coupled receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
cellular response to nutrient levels
negative regulation of TOR signaling
intracellular signal transduction
TORC1 signaling
negative regulation of cell size
negative regulation of TORC2 signaling
negative regulation of TORC1 signaling
regulation of extrinsic apoptotic signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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