Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: NYNPLPEERP GGFAWGEGQR LGG
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: carcinoma related; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; Derlin-2; DERtrin-2; F-LAN-1; F-LANa
Gene Aliases: CGI-101; DER2; DERL2; DERtrin-2; F-LAN-1; F-LANa; FLANA; SBBI53
UniProt ID: (Human) Q9GZP9
Entrez Gene ID: (Human) 51009
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