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DERLIN-1 Polyclonal Antibody
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FIGURE: 1 / 2
DERLIN-1 Antibody (BS-11268R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Human esophagus cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with DERLIN-1 Polyclonal Antibody, Unconjugated (bs-11268R) at 1:600 overnight at 4°C, DAB staining.
Product Details
BS-11268R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DERLIN-1, amino acids 111-220.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; Derlin-1; DERtrin-1; predicted protein of HQ2577; unnamed protein product
Gene Aliases: 1110021N07Rik; AI195141; AW551338; DER-1; DER1; DERL1; Derlin-1; RGD1311835; UNQ243/PRO276
UniProt ID: (Human) Q9BUN8, (Mouse) Q99J56
Entrez Gene ID: (Human) 79139, (Mouse) 67819, (Rat) 362912
response to unfolded protein
proteasomal protein catabolic process
protein transport
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
positive regulation of protein ubiquitination
protein destabilization
cellular response to stress
cellular response to unfolded protein
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
establishment of protein localization
cellular response to misfolded protein
transport
ER-associated ubiquitin-dependent protein catabolic process
positive regulation of protein binding
protein homooligomerization
ER-associated misfolded protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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