Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
Immunoprecipitation (IP) |
1:100-1:500 | - |
Product Specifications | |
---|---|
Species Reactivity |
Amphibian, Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human DGCR8. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.15 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7, with 20% glycerol |
Contains |
0.025% ProClin 300 |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2606318 |
Recommended positive controls: 293T, A431, HeLa, and HepG2 cells.
Predicted reactivity: Mouse (82%), Rat (80%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; Microprocessor complex subunit DGCR8
Gene Aliases: C22orf12; DGCR8; DGCRK6; Gy1; LP4941; pasha
UniProt ID: (Human) Q8WYQ5
Entrez Gene ID: (Human) 54487
Molecular Function:
RNA metabolism protein
RNA processing factor
nucleic acid metabolism protein
scaffold/adaptor protein
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