PA5-27944 targets Seladin 1 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-27944 immunogen is recombinant fragment corresponding to a region within amino acids 55 and 358 of Human Seladin 1.
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This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
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Protein Aliases: 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol Delta-24-reductase; DCE; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; Diminuto/dwarf1 homolog; Nbla03646; seladin 1; Seladin-1; SELADIN1; selective AD indicator 1
Gene Aliases: 2310076D10Rik; 5830417J06Rik; DCE; DHCR24; KIAA0018; mKIAA0018; Nbla03646; seladin-1; SELADIN1