Immunogen sequence: EIGSVTPKPQ EGNPRPRVFR LPEDQAVINR YGFNSHGLSV VEHRLRARQQ KQAKLTEDGL PLGVNLGKNK TSVDAAEDYA EGVRVLGPLA DYLVVNVSSP NTAGLRSLQG KAELRRLLTK VLQERDGLRR VHRPAVLVKI APDLTSQDKE DIASVVKELG IDGLIVTNTT VSRPAGLQGA LRSETGGLSG KPLRDLSTQT IREMYALTQG RVPIIGVGGV SSGQDALEKI RAGASLVQLY TALTFWGPPV VGKVKRELEA LLKEQGFGGV TDAIGADHRR; Positive Samples: MCF7, HL-60, SW620, HepG2, Mouse heart, Mouse spleen, Mouse kidney, Rat heart, Rat kidney; Cellular Location: Mitochondrion inner membrane, Single-pass membrane protein
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008].
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Protein Aliases: DHOdehase; Dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; Dihydroorotate oxidase; human complement of yeast URA1
Gene Aliases: 2810417D19Rik; AI834883; DHOdehase; DHODH; POADS; URA1
Molecular Function: dehydrogenase